Advantage of SMTube over the traditional Schirmer test is its swiftness and handiness in measuring tear volume.  Applicable  circumstance of exploiting the advantage of SMTube is not only for dry eye diagnosis. A variety  of application in clinical research  and experiments have been reported.

1. Monitoring the change in tear volume associated with certain tasks (such as VDTwork)

2. Time series variation of the amount of tears before and after a certain treatment and medication.

3. Screening of a number of subjects such as group health checkup.

4. It is also suitable for tear volume evaluation in pediatrics, owing to its minimal invasiveness.